EEG recordings from a Grin2b+/- rat model of GRIN2B neurodevelopmental disorder: absence seizures and sleep-wake abnormalities
ID: 001888
DRAFT
DRAFT
Contact Gonzalez-Sulser, Alfredo
File Count 2
Size 741 MB
Created July 7, 2026
Last update July 7, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
Chronic wireless EEG and EMG recordings from freely behaving Long-Evans rats carrying a heterozygous knockout of Grin2b (Grin2b+/-), the gene encoding the GluN2B subunit of N-methyl-D-aspartate receptors (NMDARs). Grin2b+/- rats display spike-and-wave discharges (SWDs, the electrographic correlate of absence seizures) at higher incidence and duration than wild-type littermates, alongside reduced...
Keywords:
autism
EEG
epilepsy
NMDAR
SWD
Subject matter:
thalamic reticular nucleus
Neurodevelopmental Disorder
epilepsy
Autism
intellectual disability
Absence Seizure
Contributors
Funding information
Carnegie Trust for the Universities of Scotland
- Award Number: RIG01249
Royal Society
- Award Number: RGS\R1\221112
Wellcome Trust
- Award Number: 204804/Z/16/Z
Simons Foundation
Patrick Wild Centre
Related resources
Assets Summary
Approach
electrophysiological approach
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
1
Variable Measured
ElectricalSeries
ProcessingModule
ElectrodeGroup
Measurement Technique
multi electrode extracellular electrophysiology recording technique
analytical technique
surgical technique
Associated Projects
SFARI Autism Rat Models Consortium (ARC)