EEG recordings from a Grin2b+/- rat model of GRIN2B neurodevelopmental disorder: absence seizures and sleep-wake abnormalities
ID: 001888
DRAFT
DRAFT
Contact Gonzalez-Sulser, Alfredo
File Count 17
Size 21.3 GB
Created July 7, 2026
Last update July 31, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
Chronic wireless EEG and EMG recordings from freely behaving Long-Evans rats carrying a heterozygous knockout of Grin2b (Grin2b+/-), the gene encoding the GluN2B subunit of N-methyl-D-aspartate receptors (NMDARs). Grin2b+/- rats display spike-and-wave discharges (SWDs, the electrographic correlate of absence seizures) at higher incidence and duration than wild-type littermates, alongside reduced...
Keywords:
autism
EEG
epilepsy
NMDAR
SWD
Subject matter:
thalamic reticular nucleus
Neurodevelopmental Disorder
epilepsy
Autism
intellectual disability
Absence Seizure
Contributors
Funding information
Carnegie Trust for the Universities of Scotland
- Award Number: RIG01249
Royal Society
- Award Number: RGS\R1\221112
Wellcome Trust
- Award Number: 204804/Z/16/Z
Simons Foundation
Patrick Wild Centre
Related resources
Assets Summary
Approach
electrophysiological approach
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
16
Variable Measured
ElectricalSeries
ElectrodeGroup
ProcessingModule
Measurement Technique
multi electrode extracellular electrophysiology recording technique
analytical technique
surgical technique
Associated Projects
SFARI Autism Rat Models Consortium (ARC)