CYP2C11 Overexpression Targeting Peri-lesion Astrocytes to Improve Cognitive Function in Mice with Multi-infarct Dementia
ID: 001833
DRAFT
DRAFT
Contact Liu, Zhongwu
File Count 1
Size 194.3 kB
Created May 6, 2026
Last update May 13, 2026
Licenses: spdx:CC0-1.0
Access Information: dandi:OpenAccess
CYP2C11 is a key generating enzyme of epoxyeicosatrienoic acids (EETs). Localized EET production will promote vasodilation, increase cerebral blood flow (CBF) in hypoperfused regions, and suppress neuroinflammation, thereby potentially improving cognitive function. Thus, AAV-mediated astrocyte overexpression of CYP2C11 may provide therapeutic benefit for a large patient population with a...
Keywords:
Multiple microinfarcts
Multi-infarct dementia
Neuroinflammation
Mouse model
Subject matter:
Multi-Infarct Dementia
Contributors
Funding information
National Institutes of Health
- Award Number: NS142762
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