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CYP2C11 Overexpression Targeting Peri-lesion Astrocytes to Improve Cognitive Function in Mice with Multi-infarct Dementia

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ID: 001833DRAFT
Contact Liu, Zhongwu
File Count 1
Size 194.3 kB
Created May 6, 2026
Last update May 13, 2026
Licenses: spdx:CC0-1.0
Access Information: dandi:OpenAccess

CYP2C11 is a key generating enzyme of epoxyeicosatrienoic acids (EETs). Localized EET production will promote vasodilation, increase cerebral blood flow (CBF) in hypoperfused regions, and suppress neuroinflammation, thereby potentially improving cognitive function. Thus, AAV-mediated astrocyte overexpression of CYP2C11 may provide therapeutic benefit for a large patient population with a...

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Keywords:
Multiple microinfarcts
Multi-infarct dementia
Neuroinflammation
Mouse model
Subject matter:
Multi-Infarct Dementia
Contributors
Liu, Zhongwu
McCann, M.L.
Powell, Brianna
Landschoot Ward, Julie
Zhang, Zheng Gang ORCID logo
Chopp, Michael ORCID logo
Funding information
National Institutes of Health
- Award Number: NS142762
Related resources
A new microinfarcts model produces widespread bilateral infarcts and persistent cognitive deficits in middle-aged mice
ID: 10.1016/j.expneurol.2025.115598
Resource Type: dcite:JournalArticle
Repo: Experimental Neurology
Relation: dcite:IsDescribedBy
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May 13, 2026
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