Cholinergic interneuron control of intrastriatal GABAergic circuits targeting spiny projection neurons is disrupted in Parkinson's disease models
ID: 001832
DRAFT
DRAFT
Contact Clarke, Vernon R.J.
File Count 354
Size 4 GB
Created May 5, 2026
Last update June 5, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
This Dandiset contains all raw and primary-processed data underlying the study 'Cholinergic interneuron control of intrastriatal GABAergic circuits targeting spiny projection neurons is disrupted in Parkinson’s disease models'. Parkinson’s disease (PD) is known to alter the intrinsic properties of striatal cholinergic interneurons (ChIs). However, how PD shapes ChI control of intrastriatal...
Keywords:
Parkinson's disease
Striatum
indirect pathway medium spiny neuron
direct pathway medium spiny neuron
cholinergic interneuron
iGluR, ionotropic glutamate receptor
LTSI, low-threshold spike GABAergic interneuron
AChR, nicotinic acetylcholine receptor;
NGFI, neurogliaform interneuron
NMDAR, N-methyl-D-aspartate receptor
THI, tyrosine hydroxylase interneuron
GABAergic synaptic transmission
GABAergic extrasynaptic transmission
Contributors
Funding information
National Institutes of Health
- Award Number: R37NS034696
Aligning Science Across Parkinson's
- Award Number: ASAP020551
JPB Foundation
- Award Number: GR- 2021-2960
Protocols
Related resources
Assets Summary
Approach
microscopy approach; cell population imaging
electrophysiological approach
Data StandardRRID:SCR_015242RRID:SCR_016124
Neurodata Without Borders (NWB)
Brain Imaging Data Structure (BIDS)
Number Of Subjects
245
Variable Measured
PlaneSegmentation
ProcessingModule
OpticalChannel
TwoPhotonSeries
ImagingPlane
VoltageClampSeries
Measurement Technique
surgical technique
analytical technique
two-photon microscopy technique
voltage clamp technique