Altered developmental profile of the head-direction signal in a rat model of fragile X syndrome
DOI:
10.48324/dandi.001699/0.260917.2322
10.48324/dandi.001699/0.260917.2322
ID: 001699
0.260917.2322
0.260917.2322
Contact Dudchenko, Paul
File Count 98
Size 825.1 GB
Created September 17, 2026
Last update September 17, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess (embargoed until September 17, 2026)
Fragile X Syndrome (FXS) is a common cause of autism spectrum disorder and intellectual disability (ASD/ID), but the altered neural mechanisms underlying it remain unclear. Here, we investigate the development of the head-direction (HD) system in a rat model of FXS (Fmr1-/y rats) through electrophysiological recordings in the postsubiculum during exploration and sleep. Surprisingly, juvenile...
Keywords:
postsubiculum
autism spectrum disorder
spatial navigation
Subject matter:
Fragile X Syndrome
Fmr1 protein, rat
Contributors
Funding information
University of Edinburgh
McGill University
Simons Foundation
- Award Number: AN-AR-Rat Models-0090333
Canadian Research Chair in Systems Neuroscience
Canadian Institutes of Health Research
- Award Number: 155957
Canadian Institutes of Health Research
- Award Number: 180330
Natural Sciences and Engineering Research Council of Canada
- Award Number: RGPIN-2018-04600
Related resources
Assets Summary
Approach
behavioral approach
electrophysiological approach
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
24
Variable Measured
ProcessingModule
Position
LFP
Units
SpatialSeries
CompassDirection
ElectricalSeries
Measurement Technique
behavioral technique
spike sorting technique
analytical technique
signal filtering technique
multi electrode extracellular electrophysiology recording technique