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An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement: multi-fiber photometry data

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DOI: 10.48324/dandi.001692/0.260303.1724
ID: 0016920.260303.1724
Contact Vu, Mai-Anh
File Count 339
Size 4.5 TB
Created March 3, 2026
Last update March 3, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess

Dopamine (DA) and acetylcholine (ACh) are key neuromodulators that regulate striatal circuits underlying movement and reinforcement learning. Evidence suggests that DA and ACh systems interact, but where and how interactions are expressed across striatal regions in behaviorally relevant release dynamics remains unknown. We applied micro-fiber arrays to simultaneously measure striatum-wide DA and...

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Keywords:
striatum
dopamine
acetylcholine
multi-fiber photometry
locomotion
reward
pavlovian
Subject matter:
striatum
dopamine
acetylcholine
Contributors
Vu, Mai-Anh ORCID logo
Bouabid, Safa ORCID logo
Noggle, Christian ORCID logo
Vietti-Michelina, Stefania ORCID logo
Brimblecombe, Katherine ORCID logo
Platt, Nicola
Zhang, Liangzhu ORCID logo
Joshi, Anil ORCID logo
Cragg, Stephanie ORCID logo
Howe, Mark ORCID logo
Funding information
Michael J. Fox Foundation
- Award Number: ASAP-020370
Michael J. Fox Foundation
- Award Number: ASAP-025192
Parkinson's Foundation
- Award Number: PF-SF-JFA-836662
National Institute of Mental Health
- Award Number: R01 MH125835
National Institute of Mental Health
- Award Number: F32MH120894
Whitehall Foundation
- Award Number: Whitehall Foundation Fellowship
Klingenstein Fund
- Award Number: Klingenstein-Simons Fellowship
Simons Foundation
- Award Number: Klingenstein-Simons Fellowship
Anatomy
striatum
HTTP: //purl.obolibrary.org/obo/UBERON_0002435
dopamine
HTTP: //purl.obolibrary.org/obo/CHEBI_18243
acetylcholine
HTTP: //purl.obolibrary.org/obo/CHEBI_15355
Related resources
An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement
ID: https://doi.org/10.64898/2026.01.20.700614
Resource Type: dcite:Preprint
Repo: bioRxiv
Relation: dcite:IsDescribedBy
howe-lab-to-nwb (2024)
Resource Type: dcite:Software
Repo: GitHub
Relation: dcite:IsCompiledBy
howe-lab-to-nwb (2026)
Resource Type: dcite:Software
Repo: GitHub
Relation: dcite:IsCompiledBy
Howe Lab GitHub
Resource Type: dcite:Software
Repo: GitHub
Relation: dcite:IsSupplementedBy
Assets Summary
Species
Mus musculus - House mouse
Approach
microscopy approach; cell population imaging
Data Standard
Neurodata Without Borders (NWB)
RRID:SCR_015242
Number Of Subjects
17
Variable Measured
OpticalChannel
ImagingPlane
ProcessingModule
OnePhotonSeries
PlaneSegmentation
Measurement Technique
one-photon microscopy technique
analytical technique
surgical technique
Dandiset Actions
Files
Owners
Mai-Anh Vu
Safa-Bouabid
Versions