Retrograde transduction of dopaminergic cells in substantia nigra of rhesus monkey

Neuromodulatory systems regulate neural circuits across broad regions of the brain, and disruption of the dopaminergic system contributes to psychiatric and neurodegenerative disorders. Engineered viral vectors have been used to target the neuromodulatory systems of the nonhuman primate brain (Y. Chen et al., 2023; El-Shamayleh et al., 2016; Gray et al., 2010; Lerchner et al., 2014; Perez et al.,...