Disruption of theta-timescale spiking impairs learning but spares hippocampal replay

Rats transfected with a viral strategy to express a light-activated channel (ChR2) in PV+ neurons within the MS of PV-Cre transgenic rats. We also implanted an optic fiber targeting the MS as well as either silicon electrodes or multi-tetrode arrays targeting the hippocampus. Each of these animals received optical stimulation restricted to periods of locomotion on either a lineartrack, a W-shaped...