State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
DOI:
10.48324/dandi.001538/0.260527.1302
10.48324/dandi.001538/0.260527.1302
ID: 001538
0.260527.1302
0.260527.1302
Contact Wokosin, David
File Count 468
Size 28 GB
Created May 27, 2026
Last update May 27, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
This Dandiset contains all raw and primary-processed data underlying the study “State-dependent modulation of striatal spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease” The collection spans multimodal recordings from adult C57BL/6J mice rendered hemiparkinsonian with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the medial forebrain bundle,...
Keywords:
Parkinson's disease
neurodegeneration
dopamine depletion
striatum
levodopa-induced dyskinesia
dSPNs
iSPNs
indirect pathway spiny projection neuron
LID
muscarinic M1 receptor
CalDAG-GEFI
cholinergic interneurons
Subject matter:
Parkinson's disease
Striatum
indirect pathway medium spiny neuron
direct pathway medium spiny neuron
Contributors
Funding information
National Institutes of Health
- Award Number: NS34696
Michael J. Fox Foundation
- Award Number: ASAP020551
National Institute of Neurological Disorders and Stroke
- Award Number: NS34696
JPB Foundation
Protocols
Related resources
Assets Summary
Approach
microscopy approach; cell population imaging
optogenetic approach
electrophysiological approach
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
185
Variable Measured
ProcessingModule
ImagingPlane
OpticalChannel
PlaneSegmentation
TwoPhotonSeries
VoltageClampSeries
OptogeneticSeries
CurrentClampSeries
CurrentClampStimulusSeries
Measurement Technique
analytical technique
two-photon microscopy technique
surgical technique
voltage clamp technique
current clamp technique