Public Dandisets

Fiber photometry of SNc/SNr dopamine and GABA neuron responses to optogenetic STN and PPN stimulation in Parkinson's disease

1
ID: 001528DRAFT
Contact Hadjas, Lotfi
File Count 290
Size 68.1 GB
Created July 4, 2025
Last update August 20, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess (embargoed until August 20, 2026)

This dataset contains fiber photometry recordings examining differential responses of Parkinson's disease (PD)-vulnerable and -resilient dopamine neuron subtypes to excitatory input in freely-moving mice. The study investigates how excitatory inputs from the subthalamic nucleus (STN) and pedunculopontine nucleus (PPN) differentially modulate distinct dopaminergic and GABAergic populations in the...

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Keywords:
optogenetics
fiber photometry
SNr
STN
PPN
GABAergic neuron
Parkinson's disease
SNc
DA neurons
DA subtype marker Anxa1
PD-resilient Vglut2+ DA neurons
Subject matter:
Parkinson's Disease
SNr
STN
SNc
PPN
Contributors
Hadjas, Lotfi ORCID logo
Hollon, Nick ORCID logo
Hnasko, Thomas ORCID logo
Funding information
National Institutes of Health (NIH)
- Award Number: 1 R01 NS 138598-01A1
Aligning Science Across Parkinson's (ASAP)
- Award Number: ASAP-020600
Related resources
Parkinson’s Disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input
Resource Type: dcite:Preprint
Relation: dcite:IsDescribedBy
hnasko-lab-to-nwb
ID: https://github.com/catalystneuro/hnasko-lab-to-nwb
Resource Type: dcite:Software
Repo: Github
Relation: dcite:IsCompiledBy
Assets Summary
Species
Mus musculus - House mouse
Data Standard
Neurodata Without Borders (NWB)
RRID:SCR_015242
Number Of Subjects
120
Variable Measured
ProcessingModule
Measurement Technique
analytical technique
Dandiset Actions
Files
Metadata
Manifest
Owners
Ben Dichter
Alessandra Trapani
nhollon
Versions
DRAFT
Aug 20, 2026
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