Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
ID: 001476
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DRAFT
Contact Sharkey, Lisa
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Created June 16, 2025
Last update June 16, 2025
Licenses: spdx:CC0-1.0
Access Information: dandi:OpenAccess
The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. Here we show that UBQLN2, a ubiquitin-proteasome shuttle factor implicated in neurodegenerative diseases, is regulated by the linked actions of two retrovirus-like proteins, RTL8 and PEG10. RTL8 confers on UBQLN2 the ability to complex with and regulate...
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