Social isolation recruits amygdala–medial prefrontal cortex projections to escalate alcohol drinking in male mice
ID: 001454
DRAFT
DRAFT
Contact Keyes, Laurel R
File Count 154
Size 102 GB
Created May 19, 2025
Last update August 26, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
This dandiset contains data used in the publication: Patel, R.R., Kim, K.N., Patarino, M. et al. Social isolation recruits amygdala–medial prefrontal cortex projections to escalate alcohol drinking in male mice. Nat Neurosci (2026). https://doi.org/10.1038/s41593-026-02413-x. This dandiset includes in vivo calcium imaging of the basolateral amygdala-medial prefrontal cortex circuit in mice...
Keywords:
mouse model
BLA-mPFC Circuit
social isolation
social rank
Alcohol Use Disorder (AUD) Susceptibility
alcohol drinking
Basolateral Amygdala (BLA)
Medial Prefrontal Cortex (mPFC)
calcium imaging
optogenetics
Contributors
Patel, Reesha R
Patarino, Makenzie 
Kim, Kelly
Paminuan, Rachelle
Taschbach, Felix H.
Li, Hao
Lee, Christopher R.
van Hoek, Aniek
Cazares, Christian
Miranda, Raymundo L.
Jia, Caroline
Delahanty, Jeremy
Batra, Kanha
Wichmann, Romy
Libster, Avraham
Pereira, Talmo D
Benna, Marcus K
Joo, Bitna
White, Jesse
Funding information
Salk Institute for Biological Studies
Howard Hughes Medical Institute
The Kavli Foundation
National Institute of Mental Health
- Award Number: R01MH115920 (NIMH)
Dolby Family Fund
NIH Office of the Director Pioneer Award
- Award Number: Pioneer Award DP1-AT009925 (NCCIH)
NIH/NIDA K99/R00 Pathway to Independence Award
- Award Number: K99 DA055111
Related resources
Assets Summary
Approach
behavioral approach
microscopy approach; cell population imaging
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
36
Variable Measured
OnePhotonSeries
PlaneSegmentation
BehavioralEvents
ProcessingModule
ImagingPlane
OpticalChannel
Measurement Technique
analytical technique
behavioral technique
surgical technique
one-photon microscopy technique