Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations

Striatal acetylcholine (ACh) signaling is thought to counteract reinforcement signals, promoting extinction and behavioral flexibility. Changes in striatal ACh signals have been reported during learning, but how ACh signals for learning and extinction are spatially organized to enable region specific plasticity is unclear. We used array photometry in mice to reveal a topography of opposing...