Abnormal Striatal Activity in a Mouse Model of Impulse Control Disorder in Parkinson’s Disease
DOI:
10.48324/dandi.001177/0.250902.2127
10.48324/dandi.001177/0.250902.2127
ID: 001177
0.250902.2127
0.250902.2127
Contact Zhuang, Xiaowen
File Count 56
Size 1.8 TiB
Created September 2, 2025
Last update September 2, 2025
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
In this project, we studied cognitive behavior and striatal activity in a mouse model of impulse control disorder in Parkinson’s disease in which we administered the therapeutic dopamine D2/3R agonist, pramipexole. In food-deprived mice treated with bilateral striatal saline (healthy control) or 6-OHDA (mouse model of Parkinson’s Disease), we performed both open field locomotor assessments and...
Funding information
National Institutes of Health (NIH)
- Award Number: 1 R01 NS 101354-01A1
Parkinson’s Foundation
- Award Number: PF-PRF-836910
Aligning Science Across Parkinson’s
- Award Number: ASAP-020529
Assets Summary
Approach
electrophysiological approach
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
18
Variable Measured
SpikeEventSeries
ElectricalSeries
LFP
ElectrodeGroup
ProcessingModule
Units
Measurement Technique
analytical technique
multi electrode extracellular electrophysiology recording technique
surgical technique
spike sorting technique
signal filtering technique