Aberrant Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia
ID: 001130
DRAFT
DRAFT
Contact Nelson, Alexandra B.
File Count 1
Size 677.3 MB
Created July 31, 2024
Last update February 26, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
Action selection relies on the coordinated activity of striatal direct and indirect pathway medium spiny neurons (dMSNs and iMSNs, respectively). Loss of dopamine in Parkinson’s disease is thought to disrupt this balance. While dopamine replacement with levodopa may restore normal function, the development of involuntary movements (levodopa-induced dyskinesia [LID]) limits therapy. How chronic...
Keywords:
Parkinsonism
Levodopa-induced dyskinesia
Striatum
Direct pathway MSNs
Indirect pathway MSNs
In vivo electrophysiology
Optogenetic tagging
Subject matter:
Parkinson's disease
striatum
Funding information
National Institute of Neurological Disorders and Stroke (NINDS)
- Award Number: K08 NS081001 and F31 NS106827
Parkinson’s Disease Foundation
- Award Number: PDF-JFA-1688
Related resources
Assets Summary
Approach
electrophysiological approach
optogenetic approach
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
1
Variable Measured
ElectricalSeries
LFP
ProcessingModule
OptogeneticSeries
Units
ElectrodeGroup
Measurement Technique
spike sorting technique
multi electrode extracellular electrophysiology recording technique
signal filtering technique
surgical technique
analytical technique