Optimizing NG-CanCan Protocol Delivery with MHz Compression to Minimize Near-Electrode Ablation
DOI:
10.48324/dandi.001047/0.250701.1609
10.48324/dandi.001047/0.250701.1609
ID: 001047
0.250701.1609
0.250701.1609
Contact Silkuniene, Giedre
File Count 88
Size 17.3 GB
Created July 1, 2025
Last update July 1, 2025
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
This study advanced the Next Generation (NG) CanCan protocols by implementing MHz compression for electric pulse packet delivery. Packets were delivered at 0.2 MHz, and the compression significantly reduced near-electrode cell ablation compared to delivery at 1 Hz, while preserving effects at the center. The experiments used a four-electrode array, with YoPro-1 to evaluate cell permeabilization...
Funding information
National Institutes of Health
- Award Number: 1R21EY034258
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Associated Projects
Targeted Neuromodulation by Nanosecond Pulsed Electric Fields