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Unique functional responses differentially map onto genetic subtypes of dopamine neurons

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ID: 001038DRAFT
Contact Dombeck, Daniel A.
File Count 1238
Size 22.8 GB
Created May 24, 2024
Last update May 28, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess

Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three genetic dopamine neuron subtypes within the substantia...

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Keywords:
Fiber photometry
GCaMP6f
Dopamine
substantia nigra pars compacta
striatum
Subject matter:
substantia nigra pars compacta
dopaminergic cell groups
striatum
Slc17a6 (Mmus)
CALB1
Contributors
Azcorra, Maite ORCID logo
Gaertner, Zachary ORCID logo
Davidson, Connor
He, Qianzi ORCID logo
Kim, Hailey
Nagappan, Shivathmihai ORCID logo
Hayes, Cooper K. ORCID logo
Ramakrishnan, Charu ORCID logo
Fenno, Lief ORCID logo
Kim, Yoon Seok ORCID logo
Deisseroth, Karl ORCID logo
Longnecker, Richard ORCID logo
Awatramani, Rajeshwar ORCID logo
Dombeck, Daniel A. ORCID logo
Funding information
Michael J. Fox Foundation
- Award Number: ASAP-020600
National Institutes of Health
- Award Number: R01MH110556
National Institute of Neurological Disorders and Stroke
- Award Number: 1R01NS119690-01
National Institute on Drug Abuse
- Award Number: P50 DA044121-01A1
National Institute of General Medical Sciences
- Award Number: 5T32GM008152-34
National Cancer Institute
- Award Number: CA060553
Related resources
Unique functional responses differentially map onto genetic subtypes of dopamine neurons
ID: https://doi.org/10.1038/s41593-023-01401-9
Resource Type: dcite:JournalArticle
Repo: Nature Neuroscience
Relation: dcite:IsDescribedBy
Azcorra2023
Resource Type: dcite:Software
Repo: GitHub
Relation: dcite:IsSupplementedBy
Azcorra2023 - Raw fiber photometry recordings
ID: https://doi.org/10.5281/zenodo.7871634
Resource Type: dcite:Dataset
Repo: Zenodo
Relation: dcite:IsDerivedFrom
Azcorra2023 - Fiber photometry recordings (pre-processed to get DF/F)
ID: https://doi.org/10.5281/zenodo.7871982
Resource Type: dcite:Dataset
Repo: Zenodo
Relation: dcite:IsDerivedFrom
dombeck-lab-to-nwb
Resource Type: dcite:Software
Repo: GitHub
Relation: dcite:IsCompiledBy
Assets Summary
Species
Mus musculus - House mouse
Data Standard
Neurodata Without Borders (NWB)
RRID:SCR_015242
Number Of Subjects
105
Variable Measured
ProcessingModule
Measurement Technique
analytical technique
Dandiset Actions
Files
Owners
Ben Dichter
Szonja Weigl
d-dombeck
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