Spontaneous behaviour is structured by reinforcement without explicit reward
DOI:
10.48324/dandi.000559/0.260528.0858
10.48324/dandi.000559/0.260528.0858
ID: 000559
0.260528.0858
0.260528.0858
Contact Datta, Sandeep Robert
File Count 4425
Size 14.8 TB
Created May 28, 2026
Last update May 28, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess
Spontaneous animal behaviour is built from action modules that are concatenated by the brain into sequences. However, the neural mechanisms that guide the composition of naturalistic, self-motivated behaviour remain unknown. Here we show that dopamine systematically fluctuates in the dorsolateral striatum (DLS) as mice spontaneously express sub-second behavioural modules, despite the absence of...
Keywords:
Basal Ganglia
Neural circuits
Reward
Subject matter:
dorsal striatum
dopaminergic neuron
Contributors
Funding information
National Institutes of Health
- Award Number: RF1AG073625
Brain Research Foundation
Simons Foundation
Burroughs Wellcome Fund
Jane Coffin Childs Memorial Fund for Medical Research
Alfred P. Sloan Foundation
National Institute of Neurological Disorders and Stroke
- Award Number: NS072030
Bertarelli Program in Translational Neuroscience and Neuroengineering
National Eye Institute
- Award Number: EY012196
National Institutes of Health
- Award Number: R01NS114020
National Institutes of Health
- Award Number: U19NS113201
National Institutes of Health
- Award Number: F31NS113385
National Institutes of Health
- Award Number: F31NS122155
Related resources
Assets Summary
Approach
microscopy approach; cell population imaging
optogenetic approach
behavioral approach
Data StandardRRID:SCR_015242
Neurodata Without Borders (NWB)
Number Of Subjects
69
Variable Measured
ImagingPlane
OpticalChannel
OptogeneticSeries
ProcessingModule
Position
SpatialSeries
CompassDirection
Measurement Technique
surgical technique
analytical technique
behavioral technique