Public Dandisets

Spontaneous behaviour is structured by reinforcement without explicit reward

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DOI: 10.48324/dandi.000559/0.260528.0858
ID: 0005590.260528.0858
Contact Datta, Sandeep Robert
File Count 4425
Size 14.8 TB
Created May 28, 2026
Last update May 28, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess

Spontaneous animal behaviour is built from action modules that are concatenated by the brain into sequences. However, the neural mechanisms that guide the composition of naturalistic, self-motivated behaviour remain unknown. Here we show that dopamine systematically fluctuates in the dorsolateral striatum (DLS) as mice spontaneously express sub-second behavioural modules, despite the absence of...

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Keywords:
Basal Ganglia
Neural circuits
Reward
Subject matter:
dorsal striatum
dopaminergic neuron
Contributors
Markowitz, Jeffrey E. ORCID logo
Gillis, Winthrop ORCID logo
Jay, Maya ORCID logo
Wood, Jeffrey
Harris, Ryley W. ORCID logo
Cieszkowski, Robert
Scott, Rebecca
Brann, David ORCID logo
Koveal, Dorothy ORCID logo
Kula, Tomasz ORCID logo
Weinreb, Caleb ORCID logo
Osman, Mohammed Abdal Monium ORCID logo
Pinto, Sandra Romero ORCID logo
Uchida, Naoshige ORCID logo
Linderman, Scott W. ORCID logo
Sabatini, Bernardo ORCID logo
Datta, Sandeep Robert ORCID logo
Funding information
National Institutes of Health
- Award Number: RF1AG073625
Brain Research Foundation
Simons Foundation
Burroughs Wellcome Fund
Jane Coffin Childs Memorial Fund for Medical Research
Alfred P. Sloan Foundation
National Institute of Neurological Disorders and Stroke
- Award Number: NS072030
Bertarelli Program in Translational Neuroscience and Neuroengineering
National Eye Institute
- Award Number: EY012196
National Institutes of Health
- Award Number: R01NS114020
National Institutes of Health
- Award Number: U19NS113201
National Institutes of Health
- Award Number: F31NS113385
National Institutes of Health
- Award Number: F31NS122155
Related resources
Spontaneous behaviour is structured by reinforcement without explicit reward
ID: https://doi.org/10.1038/s41586-022-05611-2
Resource Type: dcite:JournalArticle
Repo: Nature
Relation: dcite:IsDescribedBy
datta-lab-to-nwb
Resource Type: dcite:Software
Repo: GitHub
Relation: dcite:IsCompiledBy
Dandiset 000559 Example Notebook
Resource Type: dcite:ComputationalNotebook
Repo: DANDI Archive
Relation: dcite:IsSupplementedBy
Assets Summary
Species
Homo sapiens - Human
Mus musculus - House mouse
Approach
microscopy approach; cell population imaging
optogenetic approach
behavioral approach
Data Standard
Neurodata Without Borders (NWB)
RRID:SCR_015242
Number Of Subjects
69
Variable Measured
ImagingPlane
OpticalChannel
OptogeneticSeries
ProcessingModule
Position
SpatialSeries
CompassDirection
Measurement Technique
surgical technique
analytical technique
behavioral technique
Dandiset Actions
Files
Owners
Cody Baker
Paul Adkisson-Floro
Kai Fox
Versions
0.260528.0858
May 28, 2026