Public Dandisets

Esr1+ hypothalamic-habenula neurons shape aversive states.

1
DOI: 10.48324/dandi.000473/0.261102.1657
ID: 0004730.261102.1657
Contact Le Merre, Pierre
File Count 25
Size 113.6 GB
Created November 2, 2026
Last update November 2, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess

Prefrontal cortex (PFC) high-density extracellular recordings (Neuropixels) in head-fixed mice during an aversive-conditioning task. Neuronal responses to internally generated (i.e. pathway-specific optogenetic activation, see the main article for details) and externally derived (i.e. air puffs) aversive signals have been recorded.

Keywords:
Neuropixels
Mouse
Head-fixed
Lateral Hypothalamus
Lateral Habenula
Prefrontal cortex
Aversion
Subject matter:
Lateral hypothalamic area
Lateral habenula
prefrontal cortex
Contributors
Calvigioni, Daniela ORCID logo
Fuzik, Janos ORCID logo
Le Merre, Pierre ORCID logo
Slashcheva, Marina ORCID logo
Jung, Felix ORCID logo
Ortiz, Cantin ORCID logo
Lentini, Antonio ORCID logo
Csillag, Veronika
Graziano, Marta ORCID logo
Nikolakopoulou, Ifigeneia
Weglage, Moritz ORCID logo
Lazaridis, Iakovos
Kim, Hoseok
Lenzi, Irene
Park, Hyunsoo
Reinius, Björn
Carlén, Marie ORCID logo
Meletis, Konstantinos ORCID logo
Funding information
Vetenskapsrådet
Knut och Alice Wallenbergs Stiftelse
Anatomy
Lateral hypothalamic area
HTTPS: //purl.brain-bican.org/ontology/mbao/MBA_194
Lateral habenula
HTTPS: //purl.brain-bican.org/ontology/mbao/MBA_186
prefrontal cortex
HTTP: //purl.obolibrary.org/obo/UBERON_0000451
Related resources
Github code
ID: Github
Repo: Esr1_NPX_code
Relation: dcite:IsRequiredBy
Esr1+ hypothalamic-habenula neurons shape aversive states
ID: doi:10.1038/s41593-023-01367-8
Resource Type: dcite:JournalArticle
Repo: Nature Neuroscience
Relation: dcite:IsDescribedBy
Assets Summary
Species
Mus musculus - House mouse
Approach
electrophysiological approach
optogenetic approach
behavioral approach
Data Standard
Neurodata Without Borders (NWB)
RRID:SCR_015242
Number Of Subjects
25
Variable Measured
PupilTracking
ElectrodeGroup
ElectricalSeries
ProcessingModule
OptogeneticSeries
Units
LFP
BehavioralTimeSeries
Measurement Technique
behavioral technique
analytical technique
surgical technique
spike sorting technique
multi electrode extracellular electrophysiology recording technique
signal filtering technique
Dandiset Actions
Files
Owners
Pierre Le Merre
Versions