Public Dandisets

Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

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DOI: 10.48324/dandi.000350/0.240822.1759
ID: 0003500.240822.1759
Contact Mu, Yu
File Count 12
Size 5.3 TiB
Created August 22, 2024
Last update August 22, 2024
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess

When a behavior repeatedly fails to achieve its goal, animals often give up and become passive, which can be strategic for preserving energy or regrouping between attempts. It is unknown how the brain identifies behavioral failures and mediates this behavioral-state switch. In larval zebrafish swimming in virtual reality, visual feedback can be withheld so that swim attempts fail to trigger...

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Keywords:
neuroscience
glia
astrocytes
norepinephrine
noradrenaline
learned helplessness
neuromodulation
behavioral states
evidence accumulation
zebrafish
Contributors
Mu, Yu ORCID logo
Bennett, Davis V. ORCID logo
Rubinov, Mikail ORCID logo
Lim, Jing-Xuan ORCID logo
Yang, Chao-Tsung
Tanimoto, Masashi ORCID logo
Mensh, Brett D. ORCID logo
Looger, Loren L. ORCID logo
Narayan, Sujatha ORCID logo
Ahrens, Misha B. ORCID logo
Funding information
Howard Hughes Medical Institute
- Award Number: 325171
Simons Collaboration on the Global Brain Awards
- Award Number: 542943SPI
Related resources
Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior
ID: https://doi.org/10.1016/j.cell.2019.05.050
Repo: Cell
Relation: dcite:IsDescribedBy
Assets Summary
Species
Danio rerio - Zebra fish
Approach
microscopy approach; cell population imaging
Data Standard
Neurodata Without Borders (NWB)
RRID:SCR_015242
Number Of Subjects
12
Variable Measured
TwoPhotonSeries
OpticalChannel
ProcessingModule
ImagingPlane
PlaneSegmentation
Measurement Technique
surgical technique
two-photon microscopy technique
analytical technique
Dandiset Actions
Files
Owners
Ben Dichter
Cody Baker
Yumuu
Jing-Xuan Lim
Versions
0.240822.1759
Aug 22, 2024