Public Dandisets

Phenotypic variation within and across transcriptomic cell types in mouse motor cortex

0
ID: 000008DRAFT
Contact Tolias, Andreas Savas
File Count 1328
Size 11.1 GiB
Created March 17, 2020
Last update February 12, 2026
Licenses: spdx:CC-BY-4.0
Access Information: dandi:OpenAccess

We used Patch-seq to combine patch-clamp recording, biocytin staining, and single-cell RNA sequencing of over 1300 neurons in adult mouse motor cortex, providing a comprehensive morpho-electric annotation of almost all transcriptomically defined neural cell types. Contained in this dandiset are the intracellular electrophysiological recordings. See Dandiset #35 for an additional dataset, recorded...

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Keywords:
Patch-seq
cortex
motor cortex
mouse
cell types
transcriptomics
morphology
intracellular electrophysiology
Subject matter:
primary motor cortex
Contributors
Scala, Federico ORCID logo
Kobak, Dmitry ORCID logo
Bernabucci, Matteo ORCID logo
Bernaerts, Yves ORCID logo
Cadwell, Cathryn Rene ORCID logo
Castro, Jesus Ramon ORCID logo
Hartmanis, Leonard ORCID logo
Jiang, Xiaolong ORCID logo
Laturnus, Sophie ORCID logo
Miranda, Elanine
Mulherkar, Shalaka ORCID logo
Tan, Zheng Huan
Yao, Zizhen ORCID logo
Zeng, Hongkui ORCID logo
Sandberg, Rickard ORCID logo
Berens, Philipp ORCID logo
Tolias, Andreas Savas ORCID logo
Funding information
National Institute of Mental Health
- Award Number: U19MH114830
National Institute of Mental Health
- Award Number: R01MH109556
National Eye Institute
- Award Number: EY002520
National Eye Institute
- Award Number: T32EY07001
Deutsche Forschungsgemeinschaft
- Award Number: BE5601/4-1
Cluster of Excellence “Machine Learning — New Perspectives for Science”
- Award Number: 390727645
Collaborative Research Center 1233 “Robust Vision”
- Award Number: 276693517
German Federal Ministry of Education and Research
- Award Number: FKZ 01GQ1601
German Federal Ministry of Education and Research
- Award Number: 01IS18039A
Intelligence Advanced Research Projects Activity
- Award Number: D16PC00003
Related resources
Phenotypic variation of transcriptomic cell types in mouse motor cortex
ID: doi:10.1038/s41586-020-2907-3
Resource Type: dcite:JournalArticle
Repo: Nature
Relation: dcite:IsDescribedBy
mini-atlas
Resource Type: dcite:Software
Repo: GitHub
Relation: dcite:IsDescribedBy
Phenotypic variation of transcriptomic cell types in mouse motor cortex
ID: nemo:dat-kq04hua
Resource Type: dcite:Dataset
Repo: NEMO
Relation: dcite:IsContinuedBy
Morphological reconstructions of transcriptomic cell types in mouse motor cortex
Resource Type: dcite:Dataset
Repo: BIL
Relation: dcite:IsSupplementedBy
Assets Summary
Species
Mus musculus - House mouse
Approach
electrophysiological approach
Data Standard
Neurodata Without Borders (NWB)
RRID:SCR_015242
Number Of Cells
1328
Number Of Samples
1260
Number Of Subjects
266
Variable Measured
CurrentClampStimulusSeries
CurrentClampSeries
Measurement Technique
current clamp technique
Associated Projects
BICCN
Dandiset Actions
Files
Owners
Ben Dichter
Yves Bernaerts
Dmitry Kobak
Versions
DRAFT
Feb 12, 2026